Top 10 Cancer Treatment Centers in Tennessee
Navigating a cancer diagnosis can feel overwhelming, especially when facing a serious illness. Knowing you have access to the best possible care in Tennessee is crucial. The state offers numerous cancer treatment centers with advanced therapies, cutting-edge research, and compassionate support. This list highlights ten of the top cancer treatment centers in Tennessee, offering hope and comprehensive care to those facing challenging diagnoses. We understand the urgency and emotional weight of this search, and we aim to provide you with valuable information to make informed decisions about your cancer care.
This list is not exhaustive and is intended to provide a starting point for your research. It is essential to consult with your physician or oncologist to determine the most appropriate treatment center and plan for your specific situation.
Quick Reference Comparison
Compare key features at a glance to help narrow your search
| Cancer Center | NCI Status | Top Specialties | Clinical Trials | Network | Best For |
|---|---|---|---|---|---|
| Vanderbilt-Ingram Cancer Center (Nashville) | ✓ Comprehensive | Breast, Lung, Rare Cancers, Pediatric | Extensive (400+) | Single Location | Complex/Rare Cancers |
| Sarah Cannon Cancer Institute (Multiple Locations) | — | Breast, Lung, Blood Cancers, BMT | Extensive (200+) | 20+ Locations | Regional Network Care |
| West Cancer Center & Research Institute (Memphis) | — | Breast, Lung, Hematology, Precision Medicine | Extensive | Multiple Locations | Research-Driven Care |
| Thompson Cancer Survival Center (Knoxville) | — | Breast, Lung, Colon, Prostate | Available | Single Location | East Tennessee Access |
| Baptist Cancer Center (Memphis) | — | Breast, Lung, Colon, Gynecologic | Available | Multiple Locations | Mid-South Region |
| UT Medical Center Cancer Institute (Knoxville) | — | Breast, Lung, Colon, Prostate | Available | Single Location | Academic Medical Care |
| Ascension Saint Thomas Cancer Care (Multiple) | — | Breast, Lung, GI Cancers, Hematology | Limited | Multiple Locations | Statewide Access |
| Memphis Oncology Group (Memphis) | — | Breast, Lung, Colon, Prostate | Limited | Multiple Locations | Community-Based Care |
| East Tennessee Hematology Oncology (Multiple) | — | Blood Cancers, Lymphoma, Solid Tumors | Limited | Multiple Locations | Regional East TN Care |
| Mary Crowley Cancer Research (Nashville) | — | Advanced/Refractory Cancers, Phase I/II Trials | Extensive (Trials Only) | Single Location | Innovative Trial Access |
Legend: ✓ Comprehensive = NCI-designated Comprehensive Cancer Center (highest designation) | ✓ Designated = NCI-designated Cancer Center | — = Not NCI-designated
1. Vanderbilt-Ingram Cancer Center (Nashville, TN)
Vanderbilt-Ingram Cancer Center (VICC) is Tennessee's only NCI-designated Comprehensive Cancer Center, representing the highest level of cancer care in the United States and serving as the state's premier cancer research and treatment facility.
Strengths
- NCI-designated Comprehensive Cancer Center (1 of approximately 50 nationwide)
- Consistently ranked among top 25 cancer hospitals by U.S. News & World Report
- Over 400 active clinical trials offering access to cutting-edge treatments not yet widely available
- Strong focus on precision medicine with comprehensive genomic profiling available
- Pioneer in immunotherapy research with dedicated cellular therapy programs
- Internationally recognized faculty with expertise in rare and complex cancers
- Pediatric cancer program (Monroe Carell Jr. Children's Hospital) for childhood cancers
Specialties
- Breast cancer center with high-risk screening and genetics program
- Thoracic oncology program for lung and esophageal cancers
- Hematologic malignancies (leukemia, lymphoma, myeloma) with bone marrow transplant unit
- Gastrointestinal cancers including pancreatic and hepatobiliary programs
- Rare cancer program with expertise in sarcomas and uncommon malignancies
- Pediatric hematology-oncology for childhood cancers
- Precision medicine utilizing molecular profiling and targeted therapies
Patient Support Areas
- Comprehensive psychosocial oncology services including individual counseling
- Financial counselors to help navigate insurance and identify assistance programs
- Patient navigation services coordinating complex care across specialties
- Survivorship clinic addressing long-term effects of cancer treatment
- Integrative medicine services including acupuncture and meditation
- Nutritional counseling with registered oncology dietitians
- Palliative care team integrated from diagnosis through survivorship
Things to Consider
- High patient volume may result in 2-4 week wait for initial consultations
- Complex academic medical center environment can feel overwhelming for some patients
- Parking challenges in Nashville medical center campus (valet and shuttle services available)
- Most advanced treatments and specialized trials only available at main Nashville location
- May require multiple visits for comprehensive workup and treatment planning
NCI-designated Comprehensive Cancer Centers meet the highest standards for cancer research and treatment. Only about 50 centers nationwide hold this prestigious designation, ensuring access to the latest clinical trials and innovative therapies.
2. Sarah Cannon Cancer Institute at TriStar Health (Multiple Locations)
Sarah Cannon Cancer Institute is one of the nation's leading cancer research networks, with over 20 locations across Tennessee and the Southeast, providing extensive clinical trial access and specialized cancer care.
Strengths
- One of the largest community-based cancer research networks in the United States
- Over 200 active clinical trials through Sarah Cannon Research Institute
- 20+ locations across Tennessee including Nashville, Chattanooga, and surrounding areas
- Nationally recognized for blood and marrow transplantation program
- Strong emphasis on clinical research with dedicated research coordinators
- Rapid access to newly approved therapies and innovative treatments
- Multidisciplinary tumor boards meet regularly for complex cases
Specialties
- Breast cancer program with genetic testing and high-risk screening
- Lung cancer with advanced diagnostic and interventional pulmonology
- Gastrointestinal cancers including colorectal and pancreatic programs
- Hematologic malignancies with blood and marrow transplantation
- Gynecologic oncology with minimally invasive surgical options
- Thoracic oncology including mesothelioma treatment
- Precision oncology using genomic testing and targeted therapies
Patient Support Areas
- Patient navigation services at all locations
- Survivorship programs addressing post-treatment needs
- Genetic counseling and risk assessment services
- Nutritional services and wellness programs
- Social work and counseling services
- Financial assistance and insurance navigation support
- Support groups for patients and caregivers throughout the network
Things to Consider
- Quality and availability of specialized services may vary across 20+ network locations
- Most complex treatments and advanced trials available at flagship centers
- Not NCI-designated, though extensive clinical trial access through research network
- Coordination of care across multiple locations sometimes requires additional communication
- Some cutting-edge technologies may not be available at all satellite locations
3. West Cancer Center & Research Institute (Memphis, TN)
West Cancer Center & Research Institute is Memphis's premier cancer treatment and research facility, combining comprehensive clinical care with an active research program and extensive clinical trial portfolio.
Strengths
- Largest independent cancer center in the Mid-South region
- Strong focus on cancer research with dedicated research institute
- Extensive clinical trial program with access to novel therapies
- Advanced radiation therapy including TomoTherapy and stereotactic techniques
- Comprehensive breast center with same-day diagnosis capabilities
- Precision medicine program utilizing comprehensive genomic testing
- Partnership with St. Jude Children's Research Hospital for pediatric cases
Specialties
- Breast cancer with oncoplastic surgery and genetic counseling
- Lung cancer program with screening and advanced treatments
- Hematologic malignancies including leukemia, lymphoma, and myeloma
- Gastrointestinal cancers with hepatobiliary expertise
- Prostate cancer with advanced imaging and focal therapies
- Precision oncology utilizing molecular profiling
- Clinical trials for advanced and refractory cancers
Patient Support Areas
- Comprehensive patient navigation coordinating all aspects of care
- Financial counseling and assistance with treatment costs
- Psychosocial support services and counseling
- Nutritional counseling and dietary support
- Integrative medicine including complementary therapies
- Survivorship clinic for long-term follow-up care
- Support groups for various cancer types and caregivers
Things to Consider
- Not NCI-designated, though strong research focus and clinical trial portfolio
- Memphis location requires travel for patients in other parts of Tennessee
- Some patients report wait times of 2-3 weeks for initial consultations
- Insurance and billing processes can be complex as independent center
- Satellite locations offer convenience but may have limited services compared to main center
4. Thompson Cancer Survival Center (Knoxville, TN)
Thompson Cancer Survival Center, part of Covenant Health, is East Tennessee's leading community cancer center, offering comprehensive cancer care with a focus on personalized treatment and supportive services.
Strengths
- Largest cancer program in East Tennessee serving regional patient population
- American College of Surgeons Commission on Cancer accredited program
- Advanced radiation therapy including IMRT, IGRT, and stereotactic techniques
- Comprehensive breast center with dedicated breast surgery program
- Multidisciplinary tumor boards for coordinated treatment planning
- Strong emphasis on patient education and empowerment
- Convenient East Tennessee location serving Knoxville and surrounding counties
Specialties
- Breast cancer with comprehensive screening, diagnosis, and treatment
- Lung cancer program with screening and advanced surgical techniques
- Colorectal cancer with multidisciplinary care team
- Prostate cancer treatment with radiation and surgical options
- Gynecologic cancers with specialized surgical oncology
- Head and neck cancer program
- Hematology services for blood cancers and disorders
Patient Support Areas
- Patient navigation services coordinating appointments and care
- Cancer resource center with educational materials and support
- Nutritional counseling and dietary guidance
- Social work services addressing emotional and practical needs
- Support groups for patients and families
- Look Good Feel Better and other wellness programs
- Financial counseling and assistance program navigation
Things to Consider
- Not NCI-designated with more limited clinical trial options than academic centers
- Complex or rare cancers may benefit from referral to comprehensive centers like Vanderbilt-Ingram
- Some advanced technologies not available (no proton therapy, limited immunotherapy trials)
- Community hospital setting may have fewer subspecialty oncology programs
- Wait times generally shorter than academic centers but specialist availability may be more limited
5. Baptist Cancer Center (Memphis, TN)
Baptist Cancer Center, part of Baptist Memorial Health Care, provides comprehensive cancer services throughout the Mid-South with multiple convenient locations across Tennessee and surrounding states.
Strengths
- Part of large integrated health system with multiple locations
- American College of Surgeons Commission on Cancer accredited
- Advanced radiation therapy technologies including CyberKnife and TomoTherapy
- Robotic surgery capabilities for minimally invasive cancer procedures
- Comprehensive breast health center with 3D mammography
- Participation in national clinical trial cooperative groups
- Electronic health records integration across Baptist system
Specialties
- Breast cancer with comprehensive screening and treatment services
- Lung cancer program with screening and thoracic surgery
- Colorectal cancer with advanced endoscopy and surgical options
- Prostate cancer with robotic surgery and radiation therapy
- Gynecologic oncology services
- Hematologic malignancies treatment
- Gastrointestinal cancer program
Patient Support Areas
- Patient navigation throughout treatment journey
- Social work and counseling services
- Nutritional counseling and support
- Support groups at multiple locations
- Financial assistance and insurance navigation
- Palliative care consultations available
- Cancer rehabilitation services
Things to Consider
- Not NCI-designated with more limited cutting-edge research access
- Service levels vary across multiple Baptist locations throughout region
- Clinical trial availability more limited than research-intensive centers
- Some advanced treatments may require referral to specialized centers
- Complex or rare cancers may benefit from consultation at comprehensive cancer centers
When choosing a cancer center, prioritize centers with specific expertise in your cancer type. NCI-designated comprehensive centers (Vanderbilt-Ingram in Tennessee) offer the most clinical trial options. Community centers provide excellent care for common cancers with greater convenience. Don't hesitate to seek second opinions or consult multiple centers.
6. University of Tennessee Medical Center Cancer Institute (Knoxville, TN)
The University of Tennessee Medical Center Cancer Institute provides comprehensive academic cancer care in East Tennessee, combining clinical excellence with research and education missions.
Strengths
- Academic medical center with university affiliation
- Level 1 trauma center infrastructure supporting complex cancer surgeries
- Advanced imaging and diagnostic capabilities
- Residency and fellowship programs ensuring evidence-based care
- Participation in national cooperative group clinical trials
- Multidisciplinary care teams for coordinated treatment
- State-of-the-art facilities with modern treatment technologies
Specialties
- Breast cancer program with surgical and medical oncology
- Lung cancer with thoracic surgery and pulmonology
- Colorectal cancer treatment and screening programs
- Prostate cancer with urologic oncology expertise
- Gynecologic cancer services
- Hematologic malignancies and blood disorders
- Radiation oncology with IMRT and other advanced techniques
Patient Support Areas
- Social work services addressing emotional and financial needs
- Nutritional counseling and dietary support
- Patient education programs and resources
- Support groups for patients and families
- Financial counseling services
- Palliative care team available for consultations
- Connection to university resources and community programs
Things to Consider
- Not NCI-designated with more limited access to most innovative research
- Academic teaching environment may involve residents and fellows in care
- Clinical trial portfolio smaller than NCI-designated centers
- Some cutting-edge treatments may require referral to Vanderbilt-Ingram
- Complex cases may benefit from multidisciplinary consultation at comprehensive centers
7. Ascension Saint Thomas Cancer Care (Multiple Locations)
Ascension Saint Thomas Cancer Care offers comprehensive cancer services across Tennessee through a network of facilities, providing accessible care throughout Middle Tennessee and surrounding areas.
Strengths
- Extensive network of locations throughout Tennessee
- Part of national Ascension Health system with access to resources
- American College of Surgeons Commission on Cancer accreditation
- Convenient access reducing travel burden for many patients
- Advanced radiation therapy at multiple sites
- Multidisciplinary approach to cancer care
- Integration with broader Ascension Saint Thomas health system
Specialties
- Breast cancer comprehensive services
- Lung cancer screening and treatment
- Gastrointestinal cancers including colorectal program
- Hematologic malignancies treatment
- Prostate cancer services
- Gynecologic cancer care
- Medical and radiation oncology across network
Patient Support Areas
- Patient navigation services available
- Support groups at various locations
- Nutritional counseling services
- Social work and counseling support
- Financial assistance navigation
- Spiritual care services through Ascension ministry
- Palliative care available
Things to Consider
- Not NCI-designated with limited cutting-edge research programs
- Service quality and availability varies across network locations
- Clinical trial access more limited than research-focused centers
- Complex or rare cancers may require referral to academic comprehensive centers
- Some advanced technologies not available at all locations
- Subspecialty expertise may be concentrated at main facilities
8. Memphis Oncology Group (Memphis, TN)
Memphis Oncology Group is a community-based cancer care provider with multiple locations in the Memphis metropolitan area, focusing on personalized patient-centered care.
Strengths
- Multiple convenient locations throughout Memphis area
- Community-based approach with focus on accessibility
- Experienced team of board-certified oncologists and hematologists
- Participation in select clinical trials through cooperative groups
- Comprehensive cancer services under one organization
- Emphasis on personalized treatment plans
- Established relationships with regional hospitals and health systems
Specialties
- Breast cancer medical oncology
- Lung cancer treatment
- Colorectal cancer care
- Prostate cancer medical management
- Hematologic malignancies including lymphoma and leukemia
- Gynecologic cancer medical oncology
- General medical oncology for solid tumors
Patient Support Areas
- Patient-focused care coordination
- Nutritional counseling services
- Social work support available
- Pain management services
- Support group connections
- Financial counseling and assistance program navigation
- Connection to community resources
Things to Consider
- Not NCI-designated with limited in-house research programs
- Primarily focused on medical oncology with radiation and surgery through partnerships
- Clinical trial portfolio smaller than research-intensive centers
- Complex or rare cancers may benefit from academic center consultation
- Advanced technologies like proton therapy not available
- Some patients may prefer integrated cancer center with all services on-site
9. East Tennessee Hematology Oncology Group (Multiple Locations)
East Tennessee Hematology Oncology Group (ETHOG) provides comprehensive cancer and blood disorder care across East Tennessee with multiple convenient community-based locations.
Strengths
- Multiple locations throughout East Tennessee region
- Board-certified hematologists and medical oncologists
- Community-based care with personalized attention
- Convenient access for patients in smaller communities
- Established practice with experienced physicians
- Participation in select clinical trials
- Partnerships with regional hospitals for integrated care
Specialties
- Breast cancer medical oncology
- Lung cancer treatment
- Colorectal cancer care
- Lymphoma and leukemia treatment
- Multiple myeloma and plasma cell disorders
- Solid tumor medical oncology
- Hematologic conditions and blood disorders
Patient Support Areas
- Personalized care coordination
- Supportive care services to manage treatment side effects
- Nutritional counseling available
- Connection to community support resources
- Financial counseling and assistance navigation
- Pain management support
- Patient education materials
Things to Consider
- Not NCI-designated with limited research infrastructure
- Primarily medical oncology practice with radiation and surgery through referrals
- Clinical trial access more limited than academic or research centers
- Complex cases may require consultation at comprehensive cancer centers
- Advanced therapies like immunotherapy may have limited availability
- Some patients may prefer comprehensive cancer center with all specialties integrated
10. Mary Crowley Cancer Research (Nashville, TN)
Mary Crowley Cancer Research focuses exclusively on early-phase clinical trials, offering access to innovative investigational therapies for patients with advanced cancers who have exhausted standard treatment options.
Strengths
- Exclusive focus on Phase I and Phase II clinical trial research
- Access to newest investigational therapies before wider availability
- Expertise in precision medicine and genomic-guided therapy selection
- Patient-centric trial design and compassionate care approach
- Specialized in advanced and treatment-refractory cancers
- Dedicated research coordinators managing trial participation
- Network affiliation providing access to diverse trial portfolio
Specialties
- Advanced solid tumors (various cancer types)
- Treatment-refractory cancers that have progressed on standard therapies
- Rare and uncommon malignancies
- Precision medicine trials based on tumor molecular profiling
- Immunotherapy and targeted therapy trials
- Novel combination therapy studies
- Early-phase drug development programs
Patient Support Areas
- Dedicated research coordinators guiding trial participation
- Detailed informed consent process and patient education
- Close monitoring and supportive care during trials
- Connection to broader cancer care resources as needed
- Patient advocacy and support throughout trial participation
- Coordination with primary oncology teams
- Travel assistance information for eligible trials
Things to Consider
- Research facility, not a comprehensive cancer center providing standard care
- Enrollment requires specific eligibility criteria and trial availability
- Primarily for patients with advanced disease who have exhausted standard options
- Investigational therapies carry uncertainties and potential unknown risks
- Not a replacement for primary oncology care, functions as additional resource
- Insurance coverage for trial participation varies and should be clarified upfront
Moving Forward: Finding the Right Fit
Choosing a cancer treatment center is a deeply personal decision that should balance medical expertise, convenience, and personal comfort. Consider these key factors as you evaluate your options:
- Cancer Type Expertise: Does the center specialize in your specific cancer with experienced subspecialists?
- NCI Designation: For complex or rare cancers, Vanderbilt-Ingram's NCI-Comprehensive designation offers the most extensive trial and treatment options
- Clinical Trials: Access to trials can provide cutting-edge treatment options, especially important for advanced or rare cancers
- Location: Balance travel burden against specialized expertise needs—convenience matters for frequent treatments
- Support Services: Comprehensive support improves quality of life during treatment and recovery
- Insurance: Verify coverage before committing to a center and understand out-of-pocket costs
We understand that this is a challenging time, and we are here to support you. We offer a range of resources and tools to help you navigate your cancer journey, including personalized treatment plan guides, financial assistance resources, support group directories, and doctor discussion guides.
Frequently Asked Questions
Q: What makes Vanderbilt-Ingram a Comprehensive Cancer Center?
A: Vanderbilt-Ingram Cancer Center is NCI-designated, meaning it meets the highest standards for cancer research, treatment, and education set by the National Cancer Institute. This designation ensures access to the latest clinical trials, innovative therapies, and a multidisciplinary team of experts who specialize in treating complex and rare cancers. Only about 50 centers nationwide hold this comprehensive designation.
Q: How do I choose between cancer centers in Nashville, Memphis, and Knoxville?
A: Consider your specific cancer type and which center has specialized expertise in that area, proximity to your home and support network, insurance acceptance and coverage, availability of clinical trials you may qualify for, and the center's approach to patient care and support services. Schedule consultations at multiple centers to compare options and find the best fit.
Q: Can I participate in clinical trials at these Tennessee cancer centers?
A: Yes, most of these centers participate in clinical trials. Vanderbilt-Ingram, Sarah Cannon, and West Cancer Center typically have the most extensive trial portfolios with 200-400+ active trials. Mary Crowley specializes exclusively in early-phase trials. Ask your oncologist about available trials that match your diagnosis and treatment goals.
Q: Will my insurance cover treatment at these Tennessee cancer centers?
A: Most Tennessee insurance plans are accepted at these centers, but coverage varies by specific plan and center. Contact the cancer center's financial services department before your first appointment to verify insurance coverage, understand potential out-of-pocket costs, and discuss payment options or financial assistance programs.
Q: What if I live in rural Tennessee far from these centers?
A: Many centers have satellite locations or partnerships with regional hospitals bringing care closer to home. Sarah Cannon has 20+ locations, and Ascension Saint Thomas has multiple sites statewide. Some centers offer telemedicine consultations, and travel assistance programs may be available for patients who must travel. Discuss options with the cancer center's patient services team.
Q: How important is it to see specialists for my specific cancer type?
A: Very important. Centers with specialists in your specific cancer type have more experience with the latest treatments and protocols, better outcomes, and access to disease-specific clinical trials. For rare or complex cancers, seeking care at a comprehensive cancer center like Vanderbilt-Ingram is especially beneficial due to their expertise and research focus.
Q: What supportive care services should I expect at Tennessee cancer centers?
A: Comprehensive cancer centers should offer pain and symptom management, nutritional counseling, mental health support and counseling, social work services, financial counseling and assistance, palliative care, support groups for patients and caregivers, and patient navigation. These services significantly improve quality of life during treatment and are essential components of cancer care.
Q: Are there financial assistance programs for Tennessee cancer patients?
A: Yes, many programs exist including cancer center-specific financial assistance, Tennessee Medicaid (TennCare), American Cancer Society programs, CancerCare assistance, pharmaceutical company patient assistance programs, and disease-specific foundations. Visit our grants and financial resources page for comprehensive information on available funding options.
Q: Should I get a second opinion before starting cancer treatment?
A: Absolutely. Second opinions are standard practice in cancer care and can provide valuable insights into treatment options, especially for complex or rare cancers. Most oncologists encourage and facilitate second opinions. Many patients seek opinions from both NCI-designated comprehensive centers and community centers to compare approaches and find the best fit.
Q: How quickly do I need to start treatment after a cancer diagnosis?
A: Timing varies by cancer type and stage. While prompt treatment is important, taking 1-2 weeks to research options, get second opinions, and choose the right center typically won't affect outcomes for most cancers. However, some aggressive cancers require faster action. Discuss the urgency and timing with your oncologist to understand your specific situation.
Taking the Next Step
Navigating cancer treatment can feel overwhelming, but you don't have to do it alone. Beyond choosing the right treatment center, consider exploring resources for paying for cancer treatment and connecting with others who understand your journey.
Sign up with Olive to access personalized resources and support tailored to your unique situation. We can help you understand your treatment options, navigate insurance and financial assistance, compare cancer centers, and connect with a community of support. You are not alone in this journey.